SPECTRAL CHARACTERIZATION OF 2,6-BIS(2-HYDROXYETHYL)IMIDAZO[1,5-C]QUINAZOLINE-3,5-DIONE
Ключевые слова:
imidazoquinazoline, diol, oxirane, hydroxyalkylationАннотация
The article presents the results of reactions 1phenyl-2H,6H-imidazo[1,5-c]quinazoline-3,5-dione with 2 molar excess ethylene oxide, which gives 1phenyl-2,6-bis(2-hydroxyethyl)imidazo[1,5c]quinazoline-3,5-dione. The product was isolated at high yield from the reaction mixtures and identified on the basis of IR, 1H-and 13C-NMR spectroscopy. This compound can have biological activity or may be used for the synthesis of polymer.
Библиографические ссылки
Zhang Y., Chen Z., Lou Y., Yo Y. 2,3-Disubstituted 8-arylamino-3H-imidazo[4,5g]quinazolines: A novel class of antitumor agents. European Journal of Medicinal Chemistry. 2009, No. 44. P. 448-452.
Tortorella G., Piccinb A., Tieghi A. Marcheselli L., Steurer M., Gastl G., Codeluppi K., Famac A., Santorof U., Birtolog C., Gugliotta G., Cortelazzoi S., Gugliotta L. Anagrelide treatment and cardiovascular monitoring in essenatial thrombocythemia. A prospective observational study. Leukemia Research. 2015, No. 39. P. 592-598.
Stadlbauer W., Laschober R., Lutschounig H., Schindler G., Kappe T. Halogenation reactions in position 3 of quinoline-2,4-dione systems by electrophilic substitution and halogen exchange. Monatshefte fűr Chemie. 1992. No. 123. P. 617–636.
Chen Z., Huang X., Yang H., Ding W., Gao L., Ye Z., Zhang Y., Yu, Lou Y. Antitumor effects of B-2, a novel 2,3-disubstituted 8-arylamino-3Himidazo[4,5-g]quinazoline derivative, on the human lung adenocarcinoma A549 cell line in vitro and in vivo. Chemico-Biological Interactions. 2011. No. 189. P. 90–99.
Li G., Kakarla R., Gerritz S. W., Pendri A., Mac B. A facile one-step synthesis of 5-chloroimidazo[1,5-a]quinazoline by microwave irradiation. Tetrahedron Letters. 2009. No. 50. P. 6048-6052.
Klasek A., Koristek K., Lycka A., Holcapek M. Unprecedented reactivity of 3-amino-1H,3Hquinoline-2,4-diones with urea: an efficient synthesis of 2,6-dihydro-imidazo[1,5-c]quinazoline-3,5diones. Tetrahedron. 2003. No 59. P. 1283-1288.
Загрузки
Опубликован
Выпуск
Раздел
Лицензия
Copyright (c) 2021 Szyszkowska A., Zarzyka I.

Это произведение доступно по лицензии Creative Commons «Attribution-NoDerivatives» («Атрибуция — Без производных произведений») 4.0 Всемирная.